Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C17H20N2, 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a document, author is Feng, Jia, introduce the new discover.
Catalytic asymmetric C-Si bond activation via torsional strain-promoted Rh-catalyzed aryl-Narasaka acylation
Atropisomers are important organic frameworks in bioactive natural products, drugs as well as chiral catalysts. Meanwhile, silanols display unique properties compared to their alcohol analogs, however, the catalytic synthesis of atropisomers bearing silanol groups is challenging. Here, we show a rhodium-catalyzed torsional strain-promoted asymmetric ring-opening reaction for the synthesis of alpha-silyl biaryl atropisomers. The reaction features a dynamic kinetic resolution of C(Ar)-Si bond cleavage, whose stereochemistry was controlled by a phosphoramidite ligand derived from (S)-3-methyl-1-((2,4,6-triisopropylphenyl)sulfonyl)piperazine. This work is a demonstration of an aryl-Narasaka acylation, where the C(Ar)-Si bond cleavage is promoted by the torsional strain of alpha, alpha’-disubstituted silafluorene.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 841-77-0. Computed Properties of C17H20N2.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics