Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate. In a document, author is Wang, Pei-Yi, introducing its new discovery. Category: piperazines.
Novelpiperazine-tailoredursolic acid hybrids as significant antibacterial agents targeting phytopathogensXanthomonas oryzaepv.oryzaeandX. axonopodispv.citriprobably directed by activation of apoptosis
BACKGROUND Induced apoptosis is an effective technique that can reprogram cellular physiological and pathological processes to eradicate undesirable cells using their innate systems. Inspired by this, numerous apoptosis inducers have been developed to treat animal diseases, especially in the anticancer field. However, few studies have reported on the development of inductive agents that attack plant pathogens by activation of apoptosis. With the aim of exploring and discovering apoptosis inducers that target phytopathogens, a cluster of piperazine-tailored ursolic acid (UA) hybrids was systematically fabricated. RESULTS In vitrotesting showed that the title molecules could inhibit the growth of two intractable bacterial strains, defined asXanthomonas oryzaepv.oryzaeandX. axonopodispv.citri. The corresponding lowest EC(50)values were 0.37 and 1.08 mu g mL(-1), which exceed those of UA (>400 mu g mL(-1)) and positive controls. Moreover, compounds5uand5vcould manage bacterial blightin vivousing pot experiments. Flow cytometer analysis indicted that the title compounds could induce distinct apoptotic behaviors on tested bacteria. In-depth study revealed that the introduction of designed compounds could reduce the enzyme activities of catalase and superoxide dismutase, subsequently leading to the accumulation of reactive oxygen species. CONCLUSION This study promoted the development of apoptosis initiators for managing bacterial infections in agriculture by an innovative mode of action. (c) 2020 Society of Chemical Industry
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 147081-29-6 help many people in the next few years. Category: piperazines.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics