Month: March 2021

Synthetic Route of 106261-49-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, SMILES is Cl.Cl.CN1CCN(CC1)CC2=CC=C(C(=O)O)C=C2, belongs to piperazines compound. In a article, author is Huang, Zhehao, introduce new discover of the category.

Novel piperazine-2,5-dione analogs bearing 1H-indole: Synthesis and biological effects

In this work, a series of novel piperazine-2,5-dione derivatives bearing indole analogs (2a-2q) was designed and synthesized. The synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR spectroscopy, and ESI-MS. They were then evaluated for their anti-depressant, anti-inflammatory, and analgesic activities in vivo. The experimental results revealed that all the compounds showed clear anti-depressant, anti-inflammatory, and analgesic effects at a dose of 10 mg/kg. Among them, compounds 2e and 2q exhibited the best anti-depressant effects (the percent decreases in the duration of immobility were 70.2% and 71.2%, respectively), which were similar to that of fluoxetine (67.9%) in the forced swim test. Additionally, compounds 2e and 2q also displayed good anti-inflammatory and analgesic activities. Literature reports have highlighted the anti-inflammatory and analgesic effects of anti-depressant drugs, suggesting that they may have a similar mechanism of action. Therefore, further studies to investigate the possible mechanisms of action of compounds 2e and 2q are warranted.

Synthetic Route of 106261-49-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 106261-49-8.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, in an article , author is Gungor, Tugba, once mentioned of 841-77-0, Name: 1-Benzhydrylpiperazine.

Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation

In this study, various N-heterocyclic nitro prodrugs (NHN1-16) containing pyrimidine, triazine and piperazine rings were designed and synthesized. The final compounds were identified using FT-IR, H-1 NMR, C-13 NMR as well as elemental analyses. Enzymatic activities of compounds were conducted by using HPLC analysis to investigate the interaction of substrates with Ssap-NtrB nitroreductase enzyme. MTT assay was performed to evaluate the toxic effect of compounds against Hep3B and PC3 cancer cell lines and healthy HUVEC cell. It was observed that synthesized compounds NHN1-16 exhibited different cytotoxic profiles. Pyrimidine derivative NHN3 and triazine derivative NHN5 can be good drug candidates for prostate cancer with IC50 values of 54.75 mu M and 48.9 mu M, respectively. Compounds NHN6, NHN10, NHN12, NHN14 and NHN16 were selected as prodrug candidates because of non-toxic properties against three different cell models. The NHN prodrugs and Ssap-NtrB combinations were applied to SRB assay to reveal the prodrug capabilities of these selected compounds. SRB screening results showed that the metabolites of all selected non-toxic compounds showed remarkable cytotoxicity with IC50 values in the range of 1.71-4.72 nM on prostate cancer. Among the tested compounds, especially piperazine derivatives NHN12 and NHN14 showed significant toxic effect with IC50 values of 1.75 nM and 1.79 nM against PC3 cell compared with standart prodrug CB1954 (IC50: 1.71 nM). Novel compounds NHN12 and NHN14 can be considered as promising prodrug candidates for nitroreductase-prodrug based prostate cancer therapy.

Interested yet? Read on for other articles about 841-77-0, you can contact me at any time and look forward to more communication. Name: 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, belongs to piperazines compound. In a document, author is Chen, Zhuoyao, introduce the new discover, Computed Properties of C5H12N2.

Anodic oxidation of ciprofloxacin using different graphite felt anodes: Kinetics and degradation pathways

Ciprofloxacin (CIP) is ubiquitous in the environment which poses a certain threat to human and ecology. In this investigation, the physical and electrochemical properties of graphite felt (GF) anodes which affected the anodic oxidation (AO) performance, and the CIP removal effect of GF were evaluated. The GFs were used as anodes for detection of center dot OH with coumarin (COU) as molecule probe and removal of CIP in a 150 mL electrolytic cell with Pt cathode (AO-GF/Pt system). The results showed that hydrophilic GF (B-GF) owned higher sp(3)/sp(2) and more oxygen-containing and nitrogen-containing functional groups than the hydrophobic GF (A-GF). Moreover, B-GF possessed higher oxygen evolution potential (1.12 V), more active sites and stronger center dot OH generation capacity. Above mentioned caused that B-GF exhibited more superior properties for CIP removal. The best efficiencies (96.95%, 99.83%) were obtained in the AO-B-GF/Pt system at 6.25 mA cm(-2) after 10 min (k(1), 0.356 min(-1)) and 60 min (k(2), 0.224 min(-1)), respectively. Furthermore, nine degradation pathways of CIP in AO-B-GF/Pt system were summarized as the cleavage of the piperazine ring, cyclopropyl group, quinolone ring and F atom by center dot OH. It provides new insights into the removal and degradation pathways of CIP with GF in AO system.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 109-01-3 is helpful to your research. Computed Properties of C5H12N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Computed Properties of C11H17N3, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, belongs to piperazines compound. In a document, author is Okhlopkova, L. S., introduce the new discover.

Mononuclear Antimony(V) Catecholate Complexes with Additional Pyridine Ligands

A series of triarylantimony(V) complexes withp-dimethylaminopyridine andp-cyanopyridine of the general formulas [(Cat)SbAr3(p-Me2N-Py)] (complexesI-IV) and [(Cat)SbAr3(p-CN-Py)] (complexesV-VII) has been synthesized. Their molecular structures and electrochemical properties have been studied. 3,6-Di-tert-butyl-o-benzoquinone, 4,5-piperazine-1,4-diyl-3,6-di-tert-butyl-o-benzoquinone, and 4,5-dichloro-3,6-di-tert-butyl-o-benzoquinone are used as redox-active ligands. The molecular structures of several complexes in the crystalline state are determined by X-ray diffraction analysis (CIF files CCDC nos. 1974173 (I. 0.5toluene), 1974174 (II. 2toluene), 1974175 (V), 1974176 (VI. hexane), and 1974177 (VII)). All complexes have a distorted octahedral structure, and an additional neutral pyridine ligand occupies one of the apical positions. Electrochemical transformations of the complexes are studied by cyclic voltammetry in a dichloromethane solution. The introduction of substituted pyridine into the molecule of the complex does not change the electrooxidation mechanism of the complexes. For all complexes withp-dimethylaminopyridine, both oxidation potentials are shifted to the cathodic region (0.13-0.21 V for the potential of the first oxidation process and to 0.3-0.4 V for the potential of the second oxidation process). A similar shift for the complex withp-cyanopyridine is less pronounced (0.05 V for the potential of the first oxidation process of complexVas compared to that of complexI).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 16153-81-4. Computed Properties of C11H17N3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is C8H18N2O6S2, Application In Synthesis of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, belongs to piperazines compound, is a common compound. In a patnet, author is Caram, Hugo S., once mentioned the new application about 5625-37-6.

A simple thermodynamic tool for assessing energy requirements for carbon capture using solid or liquid sorbents

Carbon capture and sequestration is known to be energy intensive and will result in 20-30 % reduction in net output of a power plant. However, a simple thermodynamic tool is currently unavailable for assessing the work of CO2 separation using a given solid or liquid sorbent. This paper provides rigorous yet simple framework of equivalent work to assess the energy requirement for CO2 capture using liquid amines or solid adsorbents. First, the theoretical minimum work is determined by assuming that each step in the sorption – desorption cycle is thermodynamically reversible. Then, irreversible heat transfer losses are added to calculate total work for the actual process. The model provides useful insights into the sorbent and process selection. The minimum work for reversible separation can be calculated merely from CO2 sorption equilibria at ambient temperature without requiring laborious data or complex models. A sorbent with low ab/adsorption heat does require less thermal energy, but this thermal energy is required at a higher temperature. Thus, contrary to conventional thinking, the equivalent work is not reduced. The irreversible heat transfer losses for the amines are mostly dictated by the amine’s circulation rate which will be minimized by using amines with the highest CO2 capacity. On an energy requirement basis, the solid adsorbent based processes cannot compete with amines because practical methods of heat recuperation from the hot regenerated adsorbent are unavailable. Without heat recuperation, the solid adsorbent processes will be attractive only if their capital advantage outweighs their higher energy use.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 5625-37-6 help many people in the next few years. Application In Synthesis of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, in an article , author is Pospisilova, Sarka, once mentioned of 841-77-0, Application In Synthesis of 1-Benzhydrylpiperazine.

Insight into antimicrobial activity of substituted phenylcarbamoyloxypiperazinylpropanols

3-[4-(Substituted)phenyl-/4-(diphenylmethyl)phenylpiperazin-1-yl]-2-hydroxypropyl-1-[(substituted)phenyl] carbamates and their salts with hydrochloric acid were synthesized, characterized, and tested in vitro against Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 as reference and quality control strains, against three methicillin-resistant isolates of S. aureus, and three isolates of vancomycin-resistant E. faecalis. All the compounds were evaluated against Mycobacterium tuberculosis H37Ra/ATCC 25177, M. kansasii DSM 44162, and M. smegmatis ATCC 700084. All of the tested compounds demonstrated very good activity against all the tested strains/isolates comparable with or better than that of clinically used drugs (ampicillin, ciprofloxacin, vancomycin, isoniazid). 1-[{(3-Trifluoromethyl)phenyl}carbamoyloxy-2-hydroxypropyl]-4-(3,4-dichlorophenyl)piperazin-1-ium chloride demonstrated the highest potency against all the tested strains/isolates (MICs ranged from 3.78 to 30.2 mu M), and 1-[{(3-trifluoromethyl)phenyl}carbamoyloxy-2-hydroxypropyl]-4-(diphenylmethyl)piperazin-1-ium chloride was the most effective against all the screened mycobacterial strains (MICs ranged from 3.64 to 14.5 mu M). All the investigated derivatives had strong antibiofilm activity against S. aureus ATCC 29123 and a synergistic or additive effect with gentamicin against isolates of E. faecalis with both intrinsic and acquired resistance to gentamicin. The screening of the cytotoxicity of the compounds was performed using human monocytic leukemia THP-1 cells. The IC50 values of the most effective compounds ranged from ca. 2.8 to 7.3 mu M; thus, it can be stated that the antimicrobial effect is closely connected with their cytotoxicity. These observations disqualify these compounds from further development as antimicrobial agents, but they can be considered potential multi-target drugs with a preferred anticancer effect with good water solubility and additional anti-infectious activity.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 841-77-0, you can contact me at any time and look forward to more communication. Application In Synthesis of 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Mazzotta, Sarah, once mentioned the application of 300543-56-0, Computed Properties of C17H19ClN2, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, molecular formula is C17H19ClN2, molecular weight is 286.8, MDL number is MFCD11519277, category is piperazines. Now introduce a scientific discovery about this category.

Exploration of piperazine-derived thioureas as antibacterial and anti-inflammatory agents. In vitro evaluation against clinical isolates of colistin-resistant Acinetobacter baumannii

A. baumannii is one of the most important multidrug-resistant microorganisms in hospital units. It is resistant to many classes of antibiotics and the development of new therapeutic strategies is necessary. The aim of this study was to evaluate the antibacterial activity of a set of piperazine-derived thioureas against 13 clinical strains of colistin-resistant A. baumannii. Six derivatives were identified to inhibit bacterial growth of 46% of the A. baumannii strains at low micromolar concentrations (Minimum Inhibitory Concentration from 1.56 to 6.25 mu M). A common structural feature in most active compounds was the presence of a 3,5-bis-trifluoromethyl phenyl ring at the thiourea function. In addition, the ability of the compounds to inhibit production of nitric oxide (NO) was examined in RAW 264.7 murine macrophages, highlighting the potential of piperazine-derived thioureas as promising scaffolds for the design of new combined anti-bacterial/anti-inflammatory agents.

If you are interested in 300543-56-0, you can contact me at any time and look forward to more communication. Computed Properties of C17H19ClN2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Related Products of 300543-56-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, SMILES is ClC1=CC=C([C@H](N2CCNCC2)C3=CC=CC=C3)C=C1, belongs to piperazines compound. In a article, author is Ju, Xiaohui, introduce new discover of the category.

Electrospun transition layer that enhances the structure and performance of thin-film nanofibrous composite membranes

Electrospun nanofibers with completely interconnected pore structures are increasingly considered as substrates for fabricating thin-film nanofibmus composite (TFNC) nanofiltration (NF) membranes. The poor adhesion between the large-pore substrate and dense selective layer has been considered as the bottleneck for wide application. This work presents the role of a transition layer on membrane structure as well as performance enhancement. Specifically, both polyethyleneimine (PEI)/polyacrylonitrile (PAN) transition layer and PAN substrate layer are formed by electrospinning. Interfacial polymerization (IP) is subsequently performed with trimesoyl chloride and piperazine. The introduction of the PEI modified transition layer improves the hydrophilicity, provides additional reaction sites for IP, and avoids the polymerization in the pores of nanofibers. The resultant composite NF membranes exhibit a compact and defect-free selective layer. Such an optimal structure leads to an excellent separation performance of 95.6% for orange II dye (MW = 350.32 g/mol) rejection and 38.5 L m(-2)h(-1) bar -1 for the pure water permeability. It exhibits stable long-term performance during low pressure (0.2 MPa) nanofiltration, which will afford significant directions for the actual application of the TFNC membranes in water purification and other fields.

Related Products of 300543-56-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 300543-56-0.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Application of 841-77-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a article, author is Chung, Wonsuk, introduce new discover of the category.

Input-Output Surrogate Models for Efficient Economic Evaluation of Amine Scrubbing CO2 Capture Processes

Carbon capture followed by utilization or storage enables carbon-intensive sectors to abate their CO2 emissions. However, complexity and nonlinearity of the capture processes hinder the incorporation of their first-principles models into analyses and optimizations of overall carbon management strategies. Accordingly, it is desirable to have a systematic method to develop a computationally less demanding surrogate model, which can replace the rigorous CO2 capture process model, for use in a high-level decision-making environment. For such purposes, the surrogate model should be able to provide multiple information needed to connect to subsequent processing steps under varying source stream conditions. This research addresses the development of surrogate models for CO2 capture processes that enjoy significantly lowered complexity while preserving the key information. A surrogate model can be constructed by fitting the input-output data generated by process simulation and optimization with the rigorous model. Following the proposed method, surrogate models for the amine-based CO2 capture processes with two representative types of amines, monoethanolamine (MEA) and piperazine (PZ), are constructed and validated. The constructed surrogate models predict the specific steam consumption rate and total equipment purchase cost based on the input information of desired capture rate and CO2 source stream condition. The predicted information is shown to agree well with the simulation result of the rigorous firstprinciples model. This surrogate modeling approach can be applied to compare different capture technologies in the context of analyzing and synthesizing a larger CCUS processing network.

Application of 841-77-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 841-77-0 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2, belongs to piperazines compound. In a document, author is Wang, Fang, introduce the new discover, Product Details of 109-01-3.

Multi-Stimuli Responsive Luminescent beta-Diketones and Difluoroboron Complexes with Heterocyclic Substituents

Emissive beta-diketones (bdks) and difluoroboron complexes (BF(2)bdks) exhibit multi-stimuli responsive luminescence, including solvatochromism, viscochromism, aggregation induced emission, thermal and mechanochromic luminescence, halochromism and pH sensing. In this study, a series of six-membered heterocycle-substituted (piperidine, morpholine, 1-methyl piperazine) bdk ligands and boron complexes were synthesized, and their luminescent properties were investigated. All the compounds exhibited red-shifted emission in more polar solvents due to intramolecular charge transfer as well as higher emission intensity in more viscous environments. In response to solubility changes in water/tetrahydrofuran mixtures, while the piperazine bdk ligand showed aggregation caused quenching, the piperidine and morpholine bdks displayed enhanced emission upon aggregation. In the solid state, all ligands exhibited mechanochromism. More dramatic halochromism was observed for the piperidine boron dye spin cast film. In solution, for the boron dyes under varying pH values (1-13), different protonated and deprotonated forms were analyzed according to the measured emission spectra.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 109-01-3. Product Details of 109-01-3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics