With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.,70261-82-4
General procedure: To a solution of 2 (0.3 g, 0.68 mmol), HATU (0.26 g, 0.68 mmol)and DIPEA (0.24 mL, 1.36 mmol) in dry CH2Cl2 (10 mL) were stirred for20 min at room temperature, the substituted anilines or benzylamines (0.68 mmol) was added slowly. The reaction mixture was stirred for 5 hat room temperature. The resulting mixture was diluted by H2O(10 mL), and extracted by EtOAc (3¡Á10 mL). The combined organiclayers were washed with brine and dried over anhydrous MgSO4, filtered,and concentrated under reduced pressure. The residue was recrystallized from the solution of MeOH-H2O (1:1) to give the amides3a-n in good yields of 80.2-88.5%.
As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.
Reference£º
Article; Qiu, Yinda; Xiao, Zhongxiang; Wang, Yanyan; Zhang, Dingfang; Zhang, Wenxin; Wang, Guangbao; Chen, Wenbin; Liang, Guang; Li, Xiaokun; Zhang, Yali; Liu, Zhiguo; Bioorganic and Medicinal Chemistry; vol. 27; 20; (2019);,
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