With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78551-60-7,tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
78551-60-7, To a solution of oxalyl chloride (762 mg, 6.00 mmol) in CH2CI2 (10 ml) in a dryice-acetone bath was added DMSO (938 mg, 12.0 mmol). After 5 min, a solution ofthe product of Step 4 (2.03 g, 5.01 mmol) in CH2CI2 (20 ml) was added and themixture was stirred for 1 h. Triethylamine (2.42 g, 23.9 mmol) was added and after 2min the cooling bath was removed. The mixture was stirred for 30 min and dilutedwith water (50 ml). CH2CI2 (100 ml) was added and the aqueous layer was extractedwith CH2CI2 (2×100 ml). The combined organic layer was washed with brine, dried(MgSO4), and concentrated to give the aldehyde, which was not further purified.To a solution of diisopropylamine (667 mg, 6.59 mmol) in THF (5 ml) in a dryice-acetone bath was added 1.6 M butyllithium in hexanes (4.13 ml, 6.61 mmol).After 5 min the mixture was put in an ice-water bath and stirred for 20 min. Thesolution was cooled in the dry ice-acetone bath again and a solution of the product of Preparative Example 1, Step 5 (1.74 g, 5.99 mmol) in THF (20 ml) was added. Themixture was stirred for 1 h. A solution of the above aldehyde in THF (30 ml) wasadded and the mixture was allowed to warm up to RT slowly and stirred for 16 h. Thereaction was quenched with saturated NH4CI (20 ml) and extracted with ether (3x100ml). The combined organic layer was washed with 5% citric acid, saturated NaHCO3,and brine, dried (Na2SO4), concentrated, and purified by column chromatography(gradient EtOAc/Hexanes 0-40%) to give the product (1.20 g, 35%). MS m/e 694
The synthetic route of 78551-60-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SCHERING CORPORATION; WO2006/14762; (2006); A1;,
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