109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
HATU (0.207 g, 0.544 mmol) was added to a solution of 3-chloro-6-(1 H- pyrazol-4-yl)-8-(trifluoromethyl)imidazo[1 ,2-a]pyridine-2-carboxylic acid (0.150 g, 0.454 mmol), 1-methyl-2-piperazinone hydrochloride (0.068 g, 0.454 mmol) and DIPEA (0. 74 mL, 0.998 mmol) in DMF (1.5 mL). The mixture was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over sodium sulfate and the solvent was evaporated. The residue was purified by reverse phase HPLC (acetonitrile/water with 0.1 % formic acid) to afford 0.020 g (9%) of the title compound as a white solid. 1H NMR (400 MHz, DMSO-c/6) delta ppm 8.74 (s, 1 H) 8.18 – 8.49 (m, 2 H) 7.94 – 8.18 (m, 1 H) 4.10 – 4.63 (m, 2 H) 3.81 – 4.10 (m, 2 H) 3.39 (t, J=5.40 Hz, 2 H) 2.86 (s, 3 H). ES-LCMS m/z: 427 (M+1 ).
109384-27-2, The synthetic route of 109384-27-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; PEAT, Andrew, James; PRICE, Daniel, J.; SHOTWELL, John, Brad; TAI, Vincent; ZHANG, Huichang; WO2011/41713; (2011); A2;,
Piperazine – Wikipedia
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