The synthetic route of 52385-79-2 has been constantly updated, and we look forward to future research findings.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52385-79-2,2-(3-Chlorophenyl)piperazine,as a common compound, the synthetic route is as follows.
52385-79-2, Example 300: 3-ri-(ethylsulfonv0-4-piperidinyl1-5-r3-(2-piperazinv0phenv?-1H- indole-7-carboxamide trifluoroacetate; EPO To a solution of 3-[1 -(ethylsulfonyl)-4-piperidinyl]-5-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)-1 /-/-indole-7-carboxamide (60 mg, 0.13 mmol) in dioxane (1.5 ml_) and water (0.5 ml_) was added 2-(3-chlorophenyl)piperazine (63.7 mg, 0.325 mmol) and potassium carbonate (90 mg, 0.650 mmol). This mixture was degassed for 5 min then tetrakis(triphenylphosphine)palladium(0) (12 mg, 0.011 mmol) was added. The resulting mixture was reacted in a microwave for 30 min at 160 C. The solid was filtered off and all solvents were evaporated. The resulting solution was re-dissolved in dichloromethane and separator was used to remove water. The mixture was concentrated to give organic solvent and then purified by Gilson Preparatory HPLC to give 21.7 mg of the title compound (27.4%). LC/MS = m/z 496.4 [M+H] Ret. Time: 1.28 min.
The synthetic route of 52385-79-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/5534; (2007); A2;,
Piperazine – Wikipedia
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