928025-56-3,928025-56-3, (S)-tert-Butyl 3-ethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 9 (0.99 g, 5.4 mmol) was suspended in phosphorus oxychloride (15.2 mL, 163.4 mmol) and N,N-dimethylaniline (0.34 mL, 2.72 mmol) was added. The mixture was heated at 105C (reflux) for 3 h. The resulting yellow-green solution was cooled to r.t. and concentrated in vacuo. The residue was azeotroped with toluene (2 x 50 mL) and dried thoroughly. The resulting yellow-green gum was dissolved in THF (40 mL) and the mixture was cooled to 0C. DIPEA (7.81 mL, 44.85 mmol) was added, followed by tert-butyl (3S)-3-ethylpiperazine-l-carboxylate (1.08 g, 5.38 mmol), then the mixture was stirred at r.t. for 2 h. The mixture was evaporated to dryness, reconstituted in EtOAc (100 mL) and washed with saturated aqueous sodium bicarbonate solution (100 mL) followed by brine (100 mL), then dried (sodium sulfate), filtered and concentrated in vacuo. The residue was purified by flash column chromatography (Isolera 4, SNAP 100 g), using 0-50% TBME in heptane as eluent, to yield the title compound (8.26 g, 78%) as a yellow oil. LCMS (ES+) [M+H]+ 379, RT 1.64 minutes (method 3).
The synthetic route of 928025-56-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HORSLEY Helen Tracey; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193169; A1; (2015);,
Piperazine – Wikipedia
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