With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
The above product 17C (460 mg, 1.66 mM) was dissolved in dichloromethane (10 mL), triethylamine (347 muL, 2.49 mM) and p-toluenesulfonyl chloride (317 mg, 1.66 mM) were added and reacted overnight. The reaction was monitored by TLC, and 5% citric acid aqueous solution was added, extracted with dichloromethane, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and subjected to column chromatography (petroleum ether/ethyl acetate=2/1) to obtain 17D ( 600 mg, yield 84%)., 170911-92-9
The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chengdu Beisikairui Biological Technology Co., Ltd.; Li Dequn; (44 pag.)CN107540636; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics