With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55276-43-2,1-Methanesulfonylpiperazine,as a common compound, the synthetic route is as follows.,55276-43-2
General procedure: To a solution of amine NHR4R5 (10.0 mmol) m MeOH was added acrylonitrile (1.5 mL). After 18 h at rt, the mixture was dry loaded onto silica gel. Elution with EtOAc provided the pure 3- aminopropionitriles 44. Reaction of acrylonitrile with l-(methylsulfonyl)piperazine provided 44a: lH NMR (200 MHz, CDCb) 3.30 – 3.20 (m, 4H), 2.78 (s, 3H), 2.80 – 2.42 (m, 8H).
As the paragraph descriping shows that 55276-43-2 is playing an increasingly important role.
Reference£º
Patent; DFH THERAPEUTICS; THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; NITZ, Theodore J.; WILD, Carl T.; MARTIN, David E.; FREED, Eric O.; (0 pag.)WO2020/6510; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics