438631-77-7, (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Method 4:Synthesis of methyl (2R)-l-r5-(3-{l-r6-(2-aminopyrimidin-5-yl)pyridin-3- yl1cvclobutyl}-l,2,4-oxadiazol-5-yl)pyridin-2-yl1piperazine-2-carboxylate (Example 38, Table 1)Ex. 99 R30Example 99 (120 mg, 0.296 mmol) is treated with R30 (361 mg, 1.48 mmol) and NMP (0.150 mL) and heated at 80 C for 48 hours. The resulting mixture is cooled to room temperature and treated with 4N HC1 in 1,4-dioxane (1.50 mL) and stirred for 1.5 hours The resulting mixture is purified by reverse-phase preparative HPLC (C-18 silica, 10- 30% acetonitrile/water/0.1% trifluoroacetic acid over 20 minutes) to afford the title compound as a trifluoroacetic acid salt (110 mg), m/z 514.8 [M+H].
438631-77-7, As the paragraph descriping shows that 438631-77-7 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; DINES, Jonathon, Alan; HUBER, John, D.; LIU, Weimin; LOKE, Pui Leng; MORWICK, Tina, Marie; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee, M.; WO2012/40139; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics