5625-67-2, Piperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A 2-l Erlenmeyer flask was charged with 2-piperazinone (36.5 g, 364 mmol), sodium carbonate (116 g, 1.10 mol), 600 ml dioxane, and 150 ml water at room temperature. To this was slowly added benzyl chloroformate (62.1 g,364 mmol) over 20 min. After the addition was complete, the mixture was stirred for 2 h, diluted with water and extracted with 2 l of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated to give a white solid.To this solid was added 500 ml CH2Cl2, triethylamine (92.6 g, 128 ml, 911 mmol), 4-dimethylaminopyridine (4.45 g, 36.4 mmol), and di-tert-butyl dicarbonate (119 g,546 mmol). After 1 h at room temperature, the mixture was diluted with water and the organics were separated, dried (MgSO4), filtered and concentrated to give a brown oil. To this oil was added 100 ml CH2Cl2 followed by 1 l hexane. The resulting white solid was collected by filtration to give 4-benzyl 1-tert-butyl 2-oxo-1,4-piperazinedicarboxylate (101 g, 81%). 1H-NMR (400 MHz, CDCl3) delta 7.45-7.29 (m, 5 H), 5.15 (s, 2H), 4.24 (s, 2 H), 3.88-3.74 (m, 2 H), 3.74-3.59 (m, 2 H), 1.54 (s, 9H).
5625-67-2, The synthetic route of 5625-67-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Lloyd, David J.; St Jean, David J.; Kurzeja, Robert J. M.; Wahl, Robert C.; Michelsen, Klaus; Cupples, Rod; Chen, Michelle; Wu, John; Sivits, Glenn; Helmering, Joan; Komorowski, Renee; Ashton, Kate S.; Pennington, Lewis D.; Fotsch, Christopher; Vazir, Mukta; Chen, Kui; Chmait, Samer; Zhang, Jiandong; Liu, Longbin; Norman, Mark H.; Andrews, Kristin L.; Bartberger, Michael D.; Van, Gwyneth; Galbreath, Elizabeth J.; Vonderfecht, Steven L.; Wang, Minghan; Jordan, Steven R.; Veniant, Murielle M.; Hale, Clarence; Nature; vol. 504; 7480; (2013); p. 437 – 440;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics