With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.
Step A:6-Bromo-2-(4-cyclopropylpiperazin-1-yl)benzothiazole; To a solution of 6-bromo-2-chlorobenzothiazole (8.2 g, 33 mmol) in EtOH (115 mL) was added Et3N (16.7 g, 165 mmol), followed by 1-cyclopropylpiperazine (5 g, 39.6 mmol). The mixture was heated at reflux for 12 h. Then the mixture was evaporated to remove EtOH. Water (120 mL) was added to the residue and the mixture was extracted with CH2CI2 (3 x 50 mL). The combined organic extracts were washed with brine, dried (Na2SO4) and concentrated to give a residue, which was purified by column chromatography on silica gel eluting with a mixture of EtOAc/petroleum ether (1 :10 with 0.1 % NH4OH added) to give 3.46 g (31 %) 6-bromo-2-(4-cyclopropylpiperazin-1-yl)benzothiazole.1H NMR (300 MHz, CDCI3): delta 7.70 (t, 1 H), 7.38 (dd, 2 H), 3.60 (d, 4 H), 2.80 (d, 4 H), 1.68 (d, 1 H), 0.50-0.39 (m, 4 H).
20327-23-5, As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.
Reference£º
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
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