With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-70-5,(S)-tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Add to the reaction flask6-bromo-3-aldehyde pyridine (2.43 g, 13 mmol) and(S) -2-methylpiperazine-1-carboxylic acid tert-butyl ester(2) (3.4 g, 17 mmol) and dichloromethane (30 mL)Sodium triacetoxyborohydride (4.3 g, 20 mmol) was added in portions.The mixture was stirred at room temperature for 12 hours, water (10 mL) was added,Dichloromethane extraction (20 mL x 3).The organic phase was washed with saturated Na2CO3 solution (40 mL)Saturated brine (40 mL), dried over anhydrous sodium sulfate, filtered,Concentrated under reduced pressure. The residue was purified by column chromatography (DCM / MeOH = 20: 1)The resulting residue was purified to give the title compound (2.2 g, white solid)Yield 45%., 169447-70-5
As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.
Reference£º
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
Piperazine – Wikipedia
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