With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154590-34-8,tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
STEP A: 4-(2-fluoro-4-methylamino-phenyl)-piperazine-1-carboxylic acid tert- butyl ester. 4-(2-Fluoro-4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (10 mmol) was dissolved into EtOH/EtOAc (50/50 ml_). SnCI22H2O (10 g) was then added. The resulting mixture was heated at 1000C for 16 h. After being cooled down, ice-H2O (100 mL) was added followed by addition of NaHCO3 until pH = 9. The resulting mixture was extracted by EtOAc (3 x 200 mL). The organic layer was collected, dried (Na2SO4), filtered, and concentrated to yield the crude title compound., 154590-34-8
As the paragraph descriping shows that 154590-34-8 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2009/79597; (2009); A1;,
Piperazine – Wikipedia
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