With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.
General procedure: To a solution of compound 19 (100 mg, 0.33 mmol) in anhydrous DMF (3 mL) was added appropriate amine (0.43 mmol), EDC (82 mg, 0.43 mmol), 1-hydroxybenzotriazole monohydrate (66 mg, 0.43 mmol), and triethylamine (43 mg, 0.43 mmol). The reaction mixture was stirred at rt overnight, and partitioned between methylene chloride and brine. The organic phase was washed with brine, water, and concentrated. The residue was separated by HPLC to provide compounds 20. For compounds 20f, 20g, and 20h whose syntheses involved the use of BOC-protected amine, the coupling product was then treated with TFA (0.5 ml) in CH2Cl2 (2 mL) at rt for 1 h. Removal of the volatiles provided the crude 20 that can be further purified by HPLC to give the title products., 21043-40-3
As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.
Reference£º
Article; Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Liu, Xuesong; Shi, Yan; Johnson, Eric F.; Donawho, Cherrie K.; Ellis, Paul A; Bouska, Jennifer J.; Osterling, Donald J.; Olson, Amanda M.; Park, Chang; Luo, Yan; Shoemaker, Alexander; Giranda, Vincent L.; Penning, Thomas D.; Bioorganic and Medicinal Chemistry; vol. 20; 15; (2012); p. 4635 – 4645;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics