With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112984-60-8,6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.
At room temperature, 20 g of yufloxacin and 400 ml of a 18% methanol solution of hydrogen chloride (i.e., methanolic hydrochloric acid) were added to a 1000 ml Erlenmeyer flask, and the material was rapidly dissolved by stirring at room temperature for 10 minutes. The resulting solution was colorless and transparent, the reaction was continued stirring for 30 minutes, filtered, and the precipitated crystals were collected. The resulting crystals were collected under vacuum at 20C. The resulting crystals were collected in the proportion of 1g: 2ml water was dissolved in water and heated to dissolve, filtered, the filtrate was collected and allowed to cool to room temperature, the filtrate was added 1 volume filtrate of acetone, stirred precipitation, the precipitation of crystals collected in 20 C under vacuum drying, the sample gradually turned white to pale yellow solid, that is the present invention is water-soluble, The obtained compounds were characterized by X-ray powder diffractometry, differential scanning calorimetry, nuclear magnetic resonance, and infrared spectroscopy, respectively, and their characterization spectra were shown in FIG. 1 to FIG. 6 as crystal B. FIG., 112984-60-8
112984-60-8 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid 124225, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Zhaoke Pharmaceutical (Hefei) Co., Ltd.; Li Xiaoyi; Dai Xiangrong; Zhou Guanqun; (20 pag.)CN107383069; (2017); A;,
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