With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
[21851 Step 1: Synthesis of tert-butyl(3R.5S?)-4-(3-formylbenzyl)-3 .5-dimethylpiperazine- 1 -carboxylate[21861 (3R,55)-tert-butyl 3 ,5-dimethylpiperazine- 1 -carboxylate (formula 8-1, 2.730 g, 12.739 mmol), 3-(bromomethyl)benzaldehyde (2.789 g, 14.013 mmol) and Cs2CO3 (8.301 g, 25.478 mmol) were mixed in acetonitrile (50 mL) at room temperature, and the mixture was stirred at the same temperature for 18 hours. The reaction mixture was filtered through a paper filter to remove solids, and the filtrate was purified by column chromatography (silicon dioxide, 120 g cartridge; ethyl acetate/hexane = from 5 % to 30 %) and concentrated to afford the desired compound (2.730 g, 64.5 %) as a yellow oil.
129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; SONG, Hyeseung; LEE, Changgon; KWAK, Dalyong; LEE, Jaeyoung; BAE, Suyeal; KIM, Yuntae; BAE, Daekwon; HA, Nina; BAE, Miseon; KIM, Jihyun; WO2015/137750; (2015); A1;,
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