59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,59702-07-7
General procedure: The following exemplary compounds were prepared analogously to Example 127.1 from Example 129A and the appropriate commercially available amines. In many cases, under the reaction conditions, mixtures of mono- and di-aminated products were obtained, and were separated by chromatography. Under argon, 1.30 g (3.01 mmol) of (4S)-1-(4-bromophenyl)-7,8-dimethoxy-N,4-dimethyl-4,5-dihydro-3H-2,3-benzodiazepine-3-carboxamide (Example 49.2A) were initially charged in 65 ml of degassed toluene. 0.37 ml (331 mg, 3.31 mmol) of 1-methylpiperazine, 405 mg (4.21 mmol) of sodium tert-butoxide and 118 mg (0.15 mmol) of chloro-(2-dicyclohexylphosphino-2,4,6-triisopropyl-1,1-biphenyl) [2-(2-amino-1,1-biphenyl)]palladium(II) (CAS [1310584-14-5]) were added. The mixture was degassed again, saturated with argon and then stirred at 80¡ã C. for 12 hours. After cooling, the mixture was added to sat. sodium bicarbonate solution and extracted with ethyl acetate. The combined organic phases were washed with sat. sodium chloride solution and dried with sodium sulphate. The solvents were removed on a rotary evaporator and the residue (1.5 g orange foam) was purified by flash chromatography (SiO2, dichloromethane/methanol 0-3-10percent). This gave 850 mg (63percent of theory) of the desired product as a yellow solid.
As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SIEGEL, STEPHAN; BAURLE, STEFAN; CLEVE, ARWED; HAENDLER, BERNARD; FERNANDEZ-MONTALVAN, AMAURY ERNESTO; MONNING, URSULA; KRAUSE, SABINE; LEJEUNE, PASCALE; SCHMEES, NORBERT; BUSEMANN, MATTHIAS; HOLTON, SIMON; KUHNKE, JOACHIM; (434 pag.)JP2015/529192; (2015); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics