694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,694499-26-8
A mixture of 3-iodo-4-difluoromethyl-nicotinic acid (860 mg, 2.88 mmol)was dissolved in N, N- dimethylformamide (5 mL), was added N, N- diisopropylethylamine(668 L , 4.04 mmol) was added and 2- (7-BTA) -Nu, Nu, Nu ‘, Nu’- tetramethyluroniumhexafluorophosphate (1.2 g, 3.2 mmol), stirred for 5 min 3-trifluoromethyl-4-(4-methyl-piperazin-1-ylmethyl) aniline (737 mg, 2.69 mmol), the reactionmixture was stirred at room temperature 26 h. After completion of thereaction system was added water, extracted with ethyl acetate twice. Thecombined organic layer was purified by column chromatography to give N- (4- (4-methyl-piperazin-1-ylmethyl) -3-trifluoromethylphenyl)-3-iodo-4-difluoromethyl-smoke amide (white solid, 1.5 g).
The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shanghai Pharmaceuticals Holding Co.,Ltd .; WAN, HUIXIN; LI, CHUNLI; SHI, Chen; Liu, Haiyan; Li, Ping; XIA, Guangxin; HAN, Yanan; (52 pag.)CN103420977; (2016); B;,
Piperazine – Wikipedia
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