With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.
260mg 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid was dissolved in 10ml of dichloromethane were added 110mg DMAP, 140mg EDCI and 130mg 2A; reacted at room temperature for 12 hours, respectively, after the reaction with 1M citric acid and washed twice with brine, the organic phase was dried over anhydrous magnesium sulfate, and rotary evaporation, purified by silica gel column chromatography to give a yellow solid 180mg, yield 47.4% ;
1235865-77-6, As the paragraph descriping shows that 1235865-77-6 is playing an increasingly important role.
Reference£º
Patent; Shandong University; Fang Hao; Li Xiaoxian; Yang Xinying; Liang Tao; Liu Renshuai; Zhou Yi; (16 pag.)CN110054625; (2019); A;,
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