21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 4-(chloromethyl)-l-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl} pyrrolidin-2-one a56 (0.26 g, 0.74 mmol, 1 eq), potassium carbonate (0.4 g, 2.96 mmol, 4 eq), 1-cyclopentylpiperazine a58 (0.34 g, 2.22 mmol, 3 eq) and a catalytic amount of sodium iodide in acetonitrile (20 ml) is stirred at reflux for 4 days. Potassium carbonate is filtered and the mixture is concentrated under vacuum, then the residue is dissolved in ethyl acetate, and washed twice with a saturated solution of aqueous sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate and concentrated under vacuum to give 0.17 g of crude material. This product is purified by chromatography over silicagel (dicloromethane/methanol/ammonia 94/6/0.6) to afford 0.052 g of 4-[(4-cyclopentylpiperazin-l-yl)methyl]-l-{4-[3-(2- methylpyrrolidin-l-yl)propoxy]phenyl} pyrrolidin-2-one 44 as an orange oil. Yield : 15 %.
21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UCB PHARMA, S.A.; WO2007/48595; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics