With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
(a) Step 1 cis-2,6-Dimethylpiperazine (0.114 g, 1.00 mmol) and potassium carbonate (0.0691 g, 0.500 mmol) were added to 4 mL of methylene chloride, and stirred at room temperature. Four milliliters of a methylene chloride solution of the 7-(bromomethyl)-6-methoxybenzofuran-3(2H)-one (0.129 g, 0.500 mmol) described in [WO2011/136319] was added dropwise, and stirring was continued for 12 hours at room temperature. The reaction solution was filtered, and the residue obtained by concentrating the filtrate was purified by silica gel chromatography (methanol/chloroform), and 7-[(cis-3,5-dimethylpiperazin-1-yl)methyl]-6-methoxybenzofuran-3(2H)-one (0.131 g, 90percent) was obtained. 1H NMR (300 MHz, CDCl3) delta 1.03 (d, J=6.6 Hz, 6H), 1.73 (t, J=11.1 Hz, 2H), 2.82 (dd, J=2.1, 11.1 Hz, 2H), 2.87-2.98 (m, 2H), 3.67 (s, 2H), 3.93 (s, 3H), 4.64 (s, 2H), 6.70 (d, J=9.0 Hz, 1H), 7.62 (d, J=9.0 Hz, 1H).
21655-48-1, As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.
Reference£º
Patent; THE UNIVERSITY OF TOKYO; NAGANO, Tetsuo; NAKANO, Hirofumi; HASEGAWA, Tsukasa; SAITO, Nae; KOJIMA, Hirotatsu; OKABE, Takayoshi; MUKAIDA, Naofumi; (42 pag.)US2017/145005; (2017); A1;,
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