109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
109384-27-2, 6-Chloro-3-[(S)-1-(6-fluoro-1-methyl-1 H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazine(Intermediate E, SO.Omg, 0.152 mmol), KF (26.4mg, 0.455 mmol) and 1-methylperazine-2- one hydrochloride (51.9mg, 0.455 mmol) were suspended in NMP (1 ml_). The RM was stirred at 180 0C for 5 h. The mixture was diluted with EtOAc and washed with NaHCO3 10% (2 x) and water (4 x). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography and afforded the title compound as a light brown foam (tR 3.66 min (conditions 5), (tR 12.22 min (conditions 2), MH+ = 408.2, 1H-NMR in DMSO-d6: 7.92 (s, 1 H); 7.83 (d, 1 H); 7.49 (m, 3H); 7.11 (d, 1 H); 4.78 (m, 1H); 4.00 (d, 1H); 3.95 (S1 3H); 3.86 (d, 1 H); 3.67 (m, 2H); 3.30 (m, 2H); 2.80 (s, 3H); 1.71 (d, 3H)).
109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVARTIS AG; FURET, Pascal; McCARTHY, Clive; SCHOEPFER, Joseph; STUTZ, Stefan; WO2011/15652; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics