59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
59702-07-7, A solution of N [5-bromo-7- (3-methoxybut-1-yn-1-yl)-1, 3-benzodioxol-4-yl]-7- (3- chloropropoxy) -6-methoxyquinazolin-4-amine (0.12g, 0. 22mmol), 1-methylpiperazin-2-one (0.125g, l. lmmol) and triethylamine (0. 15ml, l. lmmol) in 2-methoxyethanol (2ml) was heated to 80 C overnight followed by heating to 100 C for a further 24 hours. The solvent was evaporated under reduced pressure and the residue was partitioned between dichloromethane and water. The organic layer was separated, dried over magnesium sulfate and evaporated under reduced pressure. Flash chromatography on silica eluting with increasingly polar solutions of methanol (0-8percent) in dichloromethane followed by trituration with diethyl ether gave the product as a racemate and in the form of a cream coloured solid (0.052g). NMR Spectrum : (d6DMSO) 1.43 (d, 3H), 1.96-1. 99 (m, 2H), 2.50-2. 55 (m, 2H), 2.64-2. 69 (m, 2H), 2.82 (s, 3H), 3.01 (s, 2H), 3.25-3. 29 (m, 2H), 3.36 (s, 3H), 3.94 (s, 3H), 4.16-4. 21 (m, 2H), 4.40 (q, 1H), 6.16 (s, 2H), 7.19 (s, 1H), 7.29 (s, 1H), 7.84 (s, 1H), 8.32 (s, 1H), 9.50 (s, 1H). Mass Spectrum : M+HF 626/628.
The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/4732; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics