934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
934-98-5, The mixture of 4-(4-chloro-1,6-naphthyridin-2-yl)-N,N-diethylbenzamide (150 mg, 0.44 mmol), 2-(4-methylpiperazin-1-yl)ethanamine (94 mg, 0.66 mmol) and K2C03 (121 mg, 0.88 mmol) in DMF (1 mL) was heated at 100¡ãC for l8hrs. The reaction mixture was poured into water (20 mL), extracted with EA (10 mL x 3). The combined organic layers were washed by water (10 mL x 3) and brine (10 mL), dried over Na2SO4. The drying agent was filtered off and the filtrate was concentrated under the reduced pressure to give the residue which was purified prep-TLC to afford N,N-diethyl-4-(4- (2-(4-methylpiperazin- 1 -yl)ethylamino)- 1 ,6-naphthyridin-2-yl)benzamide. (8 mg, 4percent). HPLC/UV purity:100percent; LC-MS (ESI): 447.2 (M + 1). ?H NMR (METHANOL-d4) oe: 9.76 (s, 1H), 8.90 (d, J = 6.2 Hz, 1H), 8.08 – 8.17 (d, J = 8.3 Hz, 2H), 7.93 (d, J = 6.2 Hz, 1H), 7.64 – 7.74 (d, J = 8.3 Hz, 2H), 7.30 (s, 1H),3.95 (t, J = 6.2 Hz, 2H), 3.63 (q, J = 6.8 Hz, 2H), 3.32 – 3.47 (m, 10H), 3.06 (t, J = 6.2 Hz, 2H), 2.92 (s,3H), 1.32 (t, J = 7.0 Hz, 3H), 1.18 (t, J = 7.0 Hz, 3H).
As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.
Reference£º
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; PINKERTON, Anthony B.; ARDECKY, Robert J.; ZOU, Jiwen; (256 pag.)WO2018/204176; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics