With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.548762-66-9,(2S,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
EXAMPLE 20 Trans-2,5-Dimethyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]piperazine dihydrochloride Using 0.34 g of trans-1-(tert-butoxycarbonyl)-2,5-dimethylpiperazine and 0.64 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.43 g of the objective compound (white crystals). m.p. 260-271 C. (decomp.) Elemental analysis (for C16 H21 N3 O2 S.2HCl) Calcd. (%): C, 48.98; H, 5.91; N, 10.71 Found (%): C, 48.79; H, 6.03; N, 10.57, 548762-66-9
As the paragraph descriping shows that 548762-66-9 is playing an increasingly important role.
Reference£º
Patent; Nippon Shinyaku Co., Ltd.; US6153608; (2000); A;,
Piperazine – Wikipedia
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