59878-57-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: A solution of 5-bromo-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione (1.0 mmol) in methanol (5 ml) was treated with the substituted piperazines or homopiperazines (2 mmol) and stirred for 24 h at ambient temperature. Compounds 8a, 8b, 8c, 8f, and 8g precipitated. The precipitates were collected by filtration and dried in vacuo to afford the solids. In the case of compounds 8d, 8e, 8h, 8i and 9a-d, the solvents of reactions were removed and the residues purified by flash column chromatography and dried to yield the pure solids.
59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Wang, Jun; Medina, Carlos; Radomski, Marek W.; Gilmer, John F.; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4985 – 4999;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics