With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5
Will 97 (0.30g, 0.88mmol),EDC.HCl (0.25 g, 1.32 mmol),HOBt (0.14 g, 1.06 mmol),A mixture of NMM (0.23 ml, 2.11 mmol) and DMF (2.5 ml) was stirred for a while, then 2-(4-methylhexahydropyrazin-1-yl)ethanamine (0.16 ml, 1.06) was added thereto at room temperature. Mmol) and stir overnight.The residue was purified by flash column on silica gel (dichloromethane:methanol=9:1, Rf=0.19) to give 49 (0.08 g, 19.47percent) as a red solid.
The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TAIPEI MEDICAL UNIVERSITY (TW); YEN, YUN (US); LIOU, JING PING (TW); PAN, SHIOW LIN (TW); (56 pag.)TW2018/5267; (2018); A;,
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