Month: April 2021

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a document, author is Oa, Seyeon, introduce the new discover, Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Effects of carbonation on carbon dioxide capture and the mechanical properties of concrete with amine sorbents

Carbon dioxide (CO2) uptake and the mechanical strength of concrete with and without carbon-dioxide-philic (CDP) amine sorbents were assessed in this study. Cement pastes with three amine-based sorbents (5-amino-1 pentanol, piperazine and 3-amino-1-propanesulfonic acid) were hydrated for 28 d. They were then assessed for carbon dioxide uptake and compressive/bending strength. The carbon dioxide in the atmosphere was sequestrated into the concrete as simulated carbonation weathering occurred, and the carbon dioxide uptake was measured using thermogravimetric analysis. Carbon dioxide uptake increased when CDP amine sorbents were mixed into the concrete specimens, with 5-amino-1-pentanol and piperazine showing the best efficiency, with carbon dioxide uptakes of 2.44% and 2.24%, respectively. The compressive and bending strengths also increased with carbonation. The strengths of the concretes with CDP sorbents were higher than that of ordinary concrete due to the microstructurel densification, indicating that urban carbon dioxide sequestration can be performed using concrete structures without damaging their structural strength.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 16153-81-4 is helpful to your research. Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C5H12N2, 109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, in an article , author is Lin, Yuqing, once mentioned of 109-01-3.

Custom-tailoring metal-organic framework in thin-film nanocomposite nanofiltration membrane with enhanced internal polarity and amplified surface crosslinking for elevated separation property

A polyamide (PA) thin-film nanocomposite (TFN) membrane embedded with post-synthetically functionalized metal-organic framework (MOF) nanofillers of imidazole-2-carbaldehyde (ICA) decorated UiO-66-NH2 nano fillers (ICA_d_UiO-66-NH2) was developed using the interfacial polymerization method. The ICA_d_UiO-66-NH2 nanofiller couples a surface water-capturing ICA decoration, facilitating the rapid transport of water molecules owing to the enhanced internal polarity, while achieving an amplified crosslinking between the terminal amine groups of ICA and trimesoyl chloride, enabling the perfect incorporation of MOF nanofillers within the PA matrix. The resultant ICA_d_UiO-66-NH2@PA TFN membrane with elevated separation property performed comparably high water permeance of 9.4 l m(-2) h(-1) bar(-1) (achieving a nearly 2-fold increase from the initial value of the thin-film composite membrane), and a favorable rejection ratio of 97.4% (Na2SO4). Owing to the unique hierarchical surface microstructure embedded with the intrinsically hydrophilic ICA_d_UiO-66-NH2 nanofillers, the newly-developed TFN membrane exhibited superior antifouling properties. Furthermore, the ICA_d_UiO-66-NH2@PA TFN membrane also retained excellent reusability and durability without significant compromise even after long-term salt, and acid/alkali treatments. Overall, this work provides an insight into the embedding of different functionalized nanofillers inside TFN membranes with elevated separation properties.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 109-01-3, you can contact me at any time and look forward to more communication. Computed Properties of C5H12N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Application In Synthesis of 1-Benzhydrylpiperazine, 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, in an article , author is Liu, Ke, once mentioned of 841-77-0.

Synthesis and biological evaluation of pyranocarbazole derivatives as Anti-tumor agents

A series of pyrano[3,2-a]carbazole alkaloids were designed and synthesized as derivatives of Girinimbine. The anticancer activities of these derivatives (3, 4a-j, 5a, 5c, 5f, 5i, 6c, 7a, 7c, 7f, 7i) against 10 cancer cell lines were studied. Among them, compounds 3 and 7i with N-methyl piperazine showed significant anticancer activity against MCF-7 cell lines with the IC50 values of 1.77 and 4.32 mu M, respectively. Furthermore, their effects on altering cell morphology, inducing cell cycle arrest and apoptosis in MCF-7 cells were studied in vitro. In addition, the molecular docking study was carried out by using Discovery Studio software to predict the interactions between these derivatives and tubulin. All in all, these consequences reveal that pyranocarbazole derivatives with N-methyl piperazine can be used as potential anticancer lead compounds and provide useful points for the further optimization of pyranocarbazole alkaloids.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 841-77-0, you can contact me at any time and look forward to more communication. Application In Synthesis of 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, molecular formula is , belongs to piperazines compound. In a document, author is Manasa, Kesari Lakshmi, Formula: C10H20N2O2.

Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: study on their apoptosis inducing ability and tubulin polymerization inhibition

A library of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone derivatives were designed, synthesized and screened for their in vitro cytotoxic activity against BT-474, HeLa, MCF-7, NCI-H460 and HaCaT cells by employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among all the synthesized analogues, compound 10ec displayed the highest cytotoxicity with the IC50 value of 0.99 +/- 0.01 mu M towards BT-474 cancer cell line. The target compound (10ec) was also evaluated for its tubulin polymerization inhibition study. Detailed biological studies such as acridine orange/ethidium bromide (AO/EB), DAPI and annexin V-FITC/propidium iodide staining assay suggested that compound 10ec induced the apoptosis of BT-474 cells. The clonogenic assay revealed that the inhibition of colony formation in BT-474 cells by 10ec in concentration-dependent manner. Moreover, the flow cytometric analysis revealed that 10ec induced apoptosis via cell cycle arrest at the sub-G1 and G2/M phase. In silico studies of sulfonyl piperazine-integrated triazole conjugates unveil that they possess drug-like properties. According to the molecular modelling studies, compound 10ec binds to the colchicine binding site of the tubulin.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 147081-29-6, in my other articles. Formula: C10H20N2O2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Let¡¯s face it, organic chemistry can seem difficult to learn, Safety of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, Especially from a beginner¡¯s point of view. Like 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, molecular formula is C9H14N4O3, belongs to amides-buliding-blocks compound. In a document, author is Zhang, Gui-Hong, introducing its new discovery.

1D/3D Co(II)-based coordination polymers: protective effect on alzheimer’s disease by inhibiting neurons apoptosis and A beta accumulation

By using a mixed-ligand method, two new Co(II)-based coordination polymers with the chemical formula of [Co(L)(2,2 ‘-bipy)](n)(1, 2,2 ‘-bipy = 4,4 ‘-bipyridine) and [Co(L)(phen)](n)(2, phen = 1,10-phenanthroline) have been successfully synthesized by the solvothermal reaction of 1,4-bis(3-carboxylbenzyl)piperazine acid (H2L) and different N-donor co-ligands with the metal salt Co(NO3)center dot 6H(2)O. Furthermore, a grinding method was used to prepare the nanoparticles of the two coordination polymers with average size distribution around 350 and 200 nm. The protective activity against the Alzheimer’s disease (AD) was assessed and the specific mechanism was discussed at the same time. First of all, the ELISA detection assay was conducted and the content of the Amyloid (A beta) in the brain was determined after compounds1and2treatment. In addition to this, the Annexin V-FITC/PI staining was performed and the protective activity of compounds1and2on neurons was evaluated.

If you are hungry for even more, make sure to check my other article about 106261-49-8, Safety of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics