129799-15-1, Methyl 1-Boc-piperazine-2-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In 9 parallel batches, A mixture of tert-butyl 2-methyl piperazine-l,2-dicarboxylate (1.0 g, 4.09 mmol), (4-fluorophenyl)boronic acid (1.72 g, 12.28 mmol), Copper(II) acetate (1.5 g, 8.19 mmol), pyridine (647 mg, 8.19 mmol) and sodium bicarbonate (688 mg, 8.19 mmol) in dichloromethane (50 ml) was stirred at ambient temperature under 02 (balloon) for 60 h, at which time LCMS indicated the reaction had gone to completion. The combined solutions were concentrated under reduced pressure. The residue was dissolved in ethyl acetate (50 mL), washed with water (2 x 40 mL) and concentrated. The crude product was purified by silica gel chromatography column (Hexanes/ethyl acetate = 5: 1) to give the title compound (9.8 g, yield 79%) as a brown oil. NMR (400 MHz, CDC13): delta 6.91 -6.80 (m, 2 H), 6.80-6.62 (m, 2 H), 4.86-4.68 (m, 1 H), 4.05-3.88 (m, 2 H), 3.77 (s, 3 H), 3.37-3.15 (m, 2 H), 2.90-2.86 (m, 1 H), 2,77-2.68 (m, 1 H), 1.49-1.40 (m, 9 H). LCMS M/Z (M+H) 338., 129799-15-1
The synthetic route of 129799-15-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; BELLON, Steven, F.; BURDICK, Daniel, J.; COTE, Alexandre; CRAWFORD, Terry; DAKIN, Les, A.; HSIAO-WEI TSUI, Vickie; HEWITT, Michael, Charles; LEBLANC, Yves; MAGNUSON, Steven, R.; NASVESCHUK, Christopher, G.; ROMERO, F., Anthony; TANG, Yong; TAYLOR, Alexander, M.; WANG, Shumei; (251 pag.)WO2016/77375; (2016); A1;,
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