59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,59878-57-8
INTERMEDIATE 48(S)-tert~BvLtyl 1 – { 8-chloro-2- F4-C cvclopropanecarbonvDpiperazin- 1 -yl] quinolin-3- vDethylcarbamateIntermediate 11 (150 mg, 0.44 mmol), cyclopropyl(piperazin-l-yl)methanone (0.16 mL, 1.1 mmol), NMP (2 mL) and DIPEA (0.38 mL, 2.2 mmol) were combined in a sealed tube and heated to 14O0C for 36 h. After cooling, Et2O was added to the reaction mixture. The organic layer was washed with water and brine. The organic layer was dried (MgSO4), filtered and the solvent was removed in vacuo. Purification by column chromatography on silica, eluting with 0-5% MeOH in EtOAc, gave the title compound (175 mg, 86%) as a yellow gum. deltaH (CDCl3) 8.00 (IH, s), 7.71 (IH, dd, J7.5, 1.3 Hz), 7.62 (IH, dd, J8.1, 1.3 Hz), 7.34-7.28 (IH, m), 5.15 (IH, br s), 4.95 (IH, br s), 3.86 (4H, br s), 3.60 (2H, br s), 3.34 (2H, br s), 1.85-1.77 (IH, m), 1.46 (3H, s), 1.44 (9H, s), 1.05- 1.00 (2H, m), 0.80 (2H, dd, J 7.8, 3.5 Hz). LCMS (ES+) 459 (M+H)+.
59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACDONALD, Jonathan, David; MATTEUCCI, Mizio; NASH, David, John; OWENS, Andrew, Pate; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; SHARPE, Andrew; WO2010/100405; (2010); A1;,
Piperazine – Wikipedia
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