With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.
A mixture of the compound of formula V (lOg) and N-(4-aminophenyl)-N-methyl-2-(4- methylpiperazin-l-yl)acetamide (formula IV) (7.89g) in DMF (50ml) was stirred at about 65-70C for 4h. The reaction mass was cooled to about 25-30C and stirred for lh. Reaction mass was filtered and solid was washed with methanol. The solid wet cake was added in methanol and stirred at about 25-30C. Reaction mass was cooled to about 0-5C and piperidine (6.2ml) was added under stirring. The reaction mass was heated to about 25-30C and stirred for 5h. The reaction mass was cooled to about 0-5C and stirred for lh. The reaction mass was filtered and solid was washed with cold methanol to obtain crude nintedanib. Yield: 12gm; HPLC purity: 99.96%; Imp B: 0.02%.
262368-30-9, The synthetic route of 262368-30-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLENMARK PHARMACEUTICALS LIMITED; NAIK, Samir; SRIVASTAVA, Sachin; PATIL, Pramod; PATIL, Premchand Bansilal; BHIRUD, Shekhar Bhaskar; (34 pag.)WO2019/48974; (2019); A1;,
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