With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5
General procedure: To a solution of 2 (0.6 mmol) in MeOH/H2O/DMSO=2:1:1(4 mL)was added sodium hydroxide (6 mmol). The solution was warmed to 45 C, after being stirred for overnight, the mixture allowed to cool, and the MeOH was removed by rotary evaporation. To the resultant slurry 1M HCl was added, and the pH was adjusted to 4. Subsequently, the mixture was filtered and washed thoroughly with water, dried to afford a white solid, which was used without additional purification. A mixture of above acid (0.3 mmol), HOBt (0.36 mmol), EDCI (0.36 mmol)were dissolved in dry DMF(3 mL), and stirred for 20 min. Then, amine(0.6 mmol) were added, the mixture was stirred for overnight, diluted with EtOAc, washed with water (30 mL¡Á5), dried over anhydrous Na2SO4, filtered and evaporated under-reduced pressure. The crude product was purified by silica gel column chromatography to afford the corresponding product 3-26.
The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Xiao, Xiao; Xu, Mei; Yang, Chao; Yao, Yao; Liang, Li-na; ED Chung, Philip; Long, Qun; Zacksenhaus, Eldad; He, Zhixu; Liu, Sheng; Ben-David, Yaacov; Bioorganic and Medicinal Chemistry; vol. 26; 23-24; (2018); p. 6096 – 6104;,
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