115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 4 6-[4-(2,4-Difluoro-phenyl)-piperazin- 1 -yl]- 1 -methyl- 1 ,5-dihydro-pyrazolo[3,4- d]pyrimidin-4-one (1-16) A microwave reaction vial was charged with 6-chloro- 1 -methyl- 1 , 5-dihydro- pyrazolo[3,4-d]pyrimidin-4-one (Intermediate A) (37 mg, 0.2 mmol), l-(2,4- difluorophenyl)piperazine (79.5 mg, 0.41 mmol), and DIPEA (77.7 mg, 0.60 mmol) in ethanol (2 mL). The vial was sealed and heated in the microwave at 140 C for 20 min. At this time, the resulting mixture was concentrated in vacuo. Flash chromatography (20/1 methylene chloride/methanol) afforded 6-[4-(2,4-difiuoro-phenyl)-piperazin- 1 -yl]- 1 -methyl- 1 ,5-dihydro- pyrazolo[3,4-d]pyrimidin-4-one (64 mg, 92.2%). H NMR (400 MHz, DMSO-d6) delta ppm 2.94 – 3.10 (m, 4 H) 3.74 (s, 3 H) 3.76 – 3.88 (m, 4 H) 7.01 (td, J=8.16, 2.76 Hz, 1 H) 7.12 (td, J=9.35, 6.15 Hz, 1 H) 7.23 (ddd, J=12.30, 9.16, 2.89 Hz, 1 H) 7.79 (s, 1 H) 11.01 (s, 1 H). LC-MS calcd. for Ci6Hi7F2N60 [(M+H)+] 347, obsd. 347.0.
115761-79-0, As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Jianwen; HAYNES, Nancy-Ellen; HERMANN, Johannes Cornelius; KIM, Kyungjin; LIU, Jin-Jun; SCOTT, Nathan Robert; YI, Lin; ZAK, Mark; ZHAO, Guiling; WO2013/182546; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics