With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
To a solution of tert-butyl 4-hydroxypiperidine-1-carboxylate (4.4 g, 21.9 mmol) in DCM (100 mL) was carefully added DMAP (5.3 g, 43.8 mmol) and triphosgene (3.2 g, 10.95 mmol) portionwise. After stirring at rt for 2 h, 1-isopropylpiperazine (3.3 g, 26 mmol) was added and the reaction mixture was stirred at rt for 5 h. The reaction was quenched with saturated NH4Cl (100 mL) solution and the mixture was extracted with DCM (3¡Á100 mL). The combined organic layers were washed with saturated NH4Cl (2¡Á100 mL) and brine (50 mL) sequentially, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the title compound as a white solid (7.7 g, 99%). [LCMS: Rt=1.67 min, m/z 356.3 (M+H)+].
4318-42-7, As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.
Reference£º
Patent; AUBERSON, Yves; Bock, Mark Gary; Braga, Dario; Curzi, Marco; Dodd, Stephanie Kay; Giaffreda, Stefano Luca; Jiang, Haiyang; Karpinski, Piotr; Troxler, Thomas J.; Wang, Tielin; Wang, Xiaoyang; Zhang, Xuechun; US2014/163036; (2014); A1;,
Piperazine – Wikipedia
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