75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 14;: 5-fluoro-2-[(3R)-3-methylpiperazin-l-yl]pyrimidine; HN,A solution of 2-chloro-5-fluoropyrimidine (239 mg, 1.80 mmol) and (R)-2-methylpiperazine (271 mg, 2.71mmol) in iPrOH (1 mL) and DIEA (617 uL) was heated in MW at 130¡ãC for 30 min. Solvent was removed under reduced pressure and the crude (600 mg) was purified by chromatography on silica using DCM/methanol (9/1) as eluent to afford The title compound as a white solid (416 mg, quantitative). TLC- DCM / MeOH(8/2); R/ 0.3. JH NMR (DMSO-d6) 5 8.14 (s, 2H), 4.48 (d, J = 13.2 Hz, 2H), 4.33 (bra,1H), 2.98-3.13 (m, 2H), 2.83 (m, 2H), 2.67 (t, J = 12.7 Hz, 1H), 1.20 (m, 3H)., 75336-86-6
75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Applied Research Systems ARS Holding N.V.; WO2006/10751; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics