170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 2-chloro-6-(2-chlorophenyl)-7-methyl-5H-pyrano[2,3-d]pyrimidin-5-one (45 mg, 0.15 mmol), tert-butyl 4-(4- aminophenyl)piperazine-1-carboxylate (41 mg, 0.15 mmol) and DIPEA (51 1JL, 0.29 mmol) in anhydrous DMF (1 mL) washeated to 100 C under a nitrogen atmosphere for 60 mm. The reaction mixture was allowed to cool to RT, diluted with water (5 mL) and extracted into ethyl acetate (3 x 5 mL) . The combined organic phases were washed with 1:1 water/brine (3 x 5 mL), dried over Na2SO4, filtered, andconcentrated to dryness under reduced pressure to givethe title compound (42 mg, 52%) as a yellow solid. ?H NMR(500 MHz, CDC13) : 6 9.18 (s, 1H) , 8.07 (br s, 1H) , 7.53(br d, 2H), 7.47-7.51 (m, 1H), 7.31-7.37 (m, 2H), 7.21-7.25 (m, 1H), 6.96 (d, 2H), 3.59 (t, 4H), 3.12 (t, 4H),2.19 (s, 3H), 1.49 (s, 9H) . LCMS (Method A): = 1.56mi m/z = 548, 550 [M+H].
170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; O’DOWD, Colin Roderick; BURKAMP, Frank; BELL, Mark Peter; WO2015/19037; (2015); A1;,
Piperazine – Wikipedia
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