169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of HOBT (0.777 g, 5.07 mmol), EDC (0.972 g, 5.07 mmol), TEA (0.707 mL,5.07 mmol) and 3-methoxy-4-nitrobenzoic acid (lg, 5.07 mmol) in DMF (20 mL) was added(S)-tert-butyl 2-methylpiperazine-1-carboxylate (1.016 g, 5.07 mmol). The reaction wasstirred at room temperature for 3 hours. The mixture was partitioned between ethyl acetate(50 mL) and water (25 mL). The organic layer was washed with water (25 mL), saturatedNaHCO3 (25 mL) and brine (25 mL), dried over Na2SO4 and evaporated in vacuum to givethe title compound D42 (1 .78g, 3.61 mmol, 71.2 % yield) as orange oil.LCMS: 380[M+H]. tR=l.325. (LCMS condition 2)
169447-70-5, The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DING, Xiao; LIU, Qian; LONG, Kai; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; XU, Qiongfeng; EDGE, Colin Michael; WO2015/113451; (2015); A1;,
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