Analyzing the synthesis route of 208167-83-3

208167-83-3 tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate 22106269, apiperazines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 15.1.2: Preparation of 4-[2-(2-Amino-benzoimidazol-l-yl)-ethyl]- piperazine-1-carboxylic acid tert-butyl ester; 4-[2-(2-Amino-benzoimidazol-l-yl)-ethyl]-piperazine-l-carboxylic acid tert-butyl ester was prepared according to the procedure described in WO2005/058869. 1H NMR (300MHz, CDCl3): delta 7.43 (IH, d, J = 7.5 Hz, Ar-CH), 7.17-7.06 (3H, m, Ar- CH), 5.78 (2H, s, NH2), 3.64 (2H, t, J = 5.7 Hz, NCH2CH2N), 3.46 (4H, m, CH2NCH2), 2.56 (4H, m, CH2NCH2), 2.43 (2H, t, J = 5.7 Hz, NCH2CH2N), 1.46 (9H, s, C[CH3J3). MS (ESI+) m/z 346 (M+ 1)., 208167-83-3

208167-83-3 tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate 22106269, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AVEXA LIMITED; WO2008/77188; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics