59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
59702-07-7, The 4-(2-hydroxyethyl)-l-methylpiperazin-2-one used as starting material was prepared as follows :-2-Bromoethanol (5.60 mL, 78.85 mmol) was added to 1 -methylpiperazin-2-one (1.80 g, 15.77 mmol) and potassium carbonate (6.54 g, 47.31 mmol) in THF (20 mL). The resulting mixture was stirred at 65¡ãC for 16 hours. The mixture was cooled to room temperature, fltered and the solvents evaporated to give crude product. The crude product was purified by flash silica chromatography, elution gradient 0 to 8percent MeOH in DCM. Pure fractions were evaporated to dryness to give 4-(2-hydroxyethyl)-l-methylpiperazin-2-one (1.870 g, 75.0percent). IH NMR (399.9 MHz, CDC13) delta 2.55 (2H, t), 2.71 (2H, t), 2.90 (3H, s), 3.15 (2H, s), 3.28 (2H, t), 3.60 (2H, t)
59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BRADBURY, Robert, Hugh; RABOW, Alfred, Arthur; WO2010/131022; (2010); A1;,
Piperazine – Wikipedia
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