With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Under an argon atmosphere,2,6-Dibromo-3-nitropyridine (1.18 g, 4.20 mmol) was added to a solution ofWas dissolved in ethanol (20 mL).there Tert-butyl 4- (4-aminophenyl) piperazine-1-carboxylate (1.40 g, 5.04 mmol)Triethylamine (1.14 mL, 8.40 mmol) was added,And the mixture was stirred at room temperature for 18 hours.The resulting precipitate was collected by filtration,After washing with a small amount of ethanol and hexane,And dried to give the title compound (1.91 g, 95%)
170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; YAKULT HONSHA COMPANY LIMITED; ABE, ATSUHIRO; MAE, MASAYUKI; YAMAZAKI, RYUTA; SASAI, TOSHIO; NISHIYAMA, HIROYUKI; NAGAOKA, MASATO; MATSUZAKI, TAKESHI; (47 pag.)JP6023630; (2016); B2;,
Piperazine – Wikipedia
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