With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.
A solution of 1 mol of N-hydroxyethylpiperazine and 40% (by mass) of aqueous potassium vinylsulfonate (containing 1.05 mol of ethylene Potassium sulfonate) was added to a 1000 mL four-necked flask equipped with a reflux tube and the addition reaction was carried out with sufficient stirring. The reaction was carried out at 50 C Should be heated for a period of 1.5 hours and then gradually heated to reflux and continue to react for 2.0 hours; then, the resulting solution containing 4-hydroxyethylpiperazine Reaction of potassium ethanesulfonate. The yield of potassium 4-hydroxyethylpiperazine ethanesulfonate was calculated by high performance liquid chromatography (HPLC) 95.1%.A reaction mother liquor containing 0.5 mol HEPES-K at a mass concentration of 35 wt% was placed in a 500 mL beaker,Under stirring,25.0 g of concentrated sulfuric acid (98 wt%) was slowly added dropwise at room temperature,Then stir,At 40 C,Acidification for 1 hour.Into the low temperature thermostat,Cooling to -20 ,Cooling crystallization for 0.5 hours,Removal of potassium sulfate by filtration.The filtrate was placed in a beaker,Constantly stirring,4.0 g of Ca (OH) 2 was slowly added,Reaction for 1 hour,Remove the remaining sulfate.Adding 5 g of activated carbon decolorization and filtering by filtration to obtain the filtrate,By rotary evaporation to anhydrous,To obtain a solid primary purified product.The solids were washed twice with 500 ml of methanol,500ml ethanol once,And then vacuum drying,Get high purity HEPES.
103-76-4, The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shandong University of Technology; Cui Hongyou; Wang Jiangang; Zhu Liwei; Liu Ransheng; Yang Yong; Wang Yang; (8 pag.)CN104803949; (2017); B;,
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