With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128019-59-0,4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
61 (B) 4-Methyl-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester The crude piperazine-1, 3-dicarboxylic acid-1-tert-butyl ester (4.92 mmol), prepared as described in 62 (A), was suspended in dry acetonitrile (30 mL) under nitrogen atmosphere and formaldehyde (37% wt. aqueous solution, 367 mL, 4.92 mmol) and Na (OAc) 3BH (2.3 g, 10. 82 mmol) were added. The resulting mixture was stirred at R. T. for 3h, then a saturated aqueous solution of NaHC03 was slowly added until the pH was adjusted to 7. The mixture was concentrated to dryness under reduced pressure to give a yellow solid that was used without further purification for the next step. LCMS (Tr): 3.19 min (Method B); MS (ES+) gave m/z : 245.0., 128019-59-0
As the paragraph descriping shows that 128019-59-0 is playing an increasingly important role.
Reference£º
Patent; ADDEX PHARMACEUTICALS SA; WO2005/44797; (2005); A1;,
Piperazine – Wikipedia
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