5753-26-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5753-26-4,1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride,as a common compound, the synthetic route is as follows.
[4-CYCLOPENTYLAMINO-6-HYDROXY-QUINAZOLINE-2-CARBONITRILE] (0. [4MMOL),] 1- (2-Chloro- ethyl) -4-methyl-piperazine dihydrochloride [(0.] [55MMOL)] and cesium carbonate [(4MMOL)] are stirred in DMF [(5ML)] at RT for 20 hours. The suspension is filtered, washed with little DMF and water is added to the filtrate until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 110- [112C,] [RIF0.] 48 [(CH2CL2/MEOH=9] : 2) is obtained. [‘H-NMR] [(CDC13)] : 1.5-1. 9 [(M,] 6H), 2.2 [(M,] 2H), 2.35 (s, 3H), 2.4-2. 75 [(M,] 8H), 2.9 [(M,] [2H),] 4.25 [(M,] 2H), 4.6 [(M,] 1H), 6.85 (broad d, 1H), 7.05 (d, 1H), 7.45 (dd, 1H), 7.8 (d, [1H).]
5753-26-4 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride 11183940, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/20441; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics