112257-12-2, tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 4-(2-bromo- acetyl)-piperazine-l-carboxylic acid tert-butyl ester (0.39 g, 1.3 mmol) and 2-nitro-6,7- dihydro-5H-imidazo[2,l-b][l,3]oxazin-6.Sr-ol (0.2 g, 1.08 mmol) in DMF (9 ml) was cooled to -60 0C and treated with sodium hydride (50 mg, 1.3 mmol) and warmed to room temperature over 2 h. The mixture was diluted with ethyl acetate, washed with water dried over sodium sulfate and concentrated. The residue is purified by silica gel chromatography (5% methanol in dichloromethane) to give 4-[2-(2-nit?>-6,7-dihydro-5H- imidazo[2,l-b][l,3]oxazin-6S-yloxy)-acetyl]-piperazine-l-carboxylic acid tert-butyl ester as a yellow oil (314 mg, 77%). ESI MS m/z 434 (M + Na+); 1H NMR (400 MHz, CDCl3) delta 7.48 (s, IH), 4.48-4.40 (m, IH), 4.40-4.22 (m, 4H), 3.38-3.44 (s, 2H), 3.42-3.30 (m, 8H), 1.42 (s, 9H)., 112257-12-2
The synthetic route of 112257-12-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; CUMBRE PHARMACEUTICALS INC.; WO2008/8480; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics