34334-28-6, 4-(4-Methylpiperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A mixture of 2-((4-chlorophenyl)thio)acetohydrazide 50(1.00 mmol), the suitably substituted nitrile (3.00 mmol), andK2CO3 (0.5 mmol) in n-BuOH (2 mL) was stirred for 16 h in a reusablesealed tube at 150 C, in an oil bath. The progress of the reactionwasmonitored by the disappearance of the hydrazide by TLCanalysis. The solvent was removed in vacuo and the residue obtainedwas purified by flash chromatography (hexanes/EtOAc 1:1).4.7. 5-(4-Chlorophenyl)-3-(((4-chlorophenyl)thio)methyl)-1H-1,2,4-triazole, 5White solid. M. p. 121e122 C. Yield: 51%. 1H-NMR (d, ppm):10.63 (bs, 1H, exc.), 7.93 (d, 2H, J 8.4 Hz), 7.42 (d, 2H, J 8.0 Hz),7.31e7.25 (m, 4H), 4.27 (s, 2H). 13C-NMR (d, ppm): 159.52, 156.95,136.28, 133.43, 132.72, 131.22, 129.41, 129.13, 128.54, 127.74, 127.49,30.34. HRMS (ESI) [M H] calculated for C15H11Cl2N3S: 335.0051,found: 335.0233., 34334-28-6
34334-28-6 4-(4-Methylpiperazin-1-yl)benzonitrile 763205, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; La Pietra, Valeria; Sartini, Stefania; Botta, Lorenzo; Antonelli, Alessandro; Ferrari, Silvia Martina; Fallahi, Poupak; Moriconi, Alessio; Coviello, Vito; Quattrini, Luca; Ke, Yi-Yu; Hsing-Pang, Hsieh; Da Settimo, Federico; Novellino, Ettore; La Motta, Concettina; Marinelli, Luciana; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 491 – 505;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics