With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154590-35-9,tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
154590-35-9, Step 4: To the product of Step 3 (0.63 g, 2.1 mmol) in CH2Cl2 (10 ml) add DIPEA (0.56 ml, 3.2 mmol), followed by AcCl (0.18 ml, 2.6 mmol). Stir 0.5 h, concentrate, and purify by PLC to obtain the amide as a brown oil
154590-35-9 tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 16203630, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Schering Corporation; US2004/220194; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics