27469-60-9, The synthetic route of 27469-60-9 has been constantly updated, and we look forward to future research findings.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27469-60-9,4,4-Difluorobenzhydrylpiperazine,as a common compound, the synthetic route is as follows.
Example 27 : Preparation of2-(2-(4-(bis(4-fluorophenyl)methyl)piperazin-l-yl)-2-oxoethylamino)-N-(4-phenyl butan-2-yl)acetamide; [371] [372] 0.5 mmol of N-((t-butyloxy)carbonyl)-N’-(l-methyl-3-phenylpropyl)iminodiacetic acid monoamide, 0.55 mmol of l-(bis(4-fluorophenyl)methyl)piperazine, and PyBOP were added to 3 mL of DMF to dissolve. Then, 1.0 mmol ofN,N-diisopropylethylamine (DIEA) was added thereto, and stirred at room temperature for 16 hours. 20 mL of 10% HCl was put into the reaction solution, and extracted with 30 mL of EtOAc. The organic layer was washed with 20 mL of 10% HCl, and then washed with 20 mL of a saturated NaHCO solution twice and with 20 mL of a saturated NaCl solution twice. The organic layer was collected, dried over anhydrous MgSO , and filtered under reduced pressure. The organic solvent in the filtrate was removed under reduced pressure. The residue was purified by column chromatography with a mixed solvent of EtOAc and methanol (20: 1), so as to obtain N- ((t-butyloxy)carbonyl)-N’-(l-methyl-3-phenylpropyl)-N”-l-(bis(4-fluorophenyl)methyl )piperazine iminodiacetic acid diamide. Chloroform (1 mL) and 4 M HCl-dioxane (1 mL) were added to the obtained compound, and left to stand for 3 hours. The solvent was removed under reduced pressure, so as to obtain the title compound (white solid, yield: 56%).[373] mp 148-1520C;[374] 1U NMR (CDCl 400MHz) delta 1.147(d, 3H, J=6.4Hz), 1.605-1.846(m, 2H),2.575-2.716(m, 2H), 3.163~3.431(m, 4H), 3.776~3.994(m, 4H), 4.052~4.214(m, 2H), 4.326~4.499(m, 2H), 5.486(br s, IH), 6.010(s, IH), 7.046- 7.247 (m, 8H), 8.173(br s, 4H), 8.520~8.650(m, IH);[375] FABHRMS (m/z):535.2885 (M++., requires C 31 H 37 N 4O 2F 2: 535.2806).
27469-60-9, The synthetic route of 27469-60-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; PARK CHOO, Hea-Young; WO2007/142431; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics