5271-27-2,5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The solution of compound 1 (150 mg, 0.64 mmol), 1-Methyl-3-phenylpiperazine (112 mg, 0.64 mmol), NaI (190 mg, 1.27 mmol) and DIPEA (0.22 ml, 1.27 mmol) DMSO (3.5 mL) was stirred at 135° C. for 48 h with oil bath. TLC was used to monitor the reaction. After cooled to room temperature, the reaction mixture was added to half-saturated ammonium chloride in water (80 mL) and stirred for 30 min. The solids were collected by filtration, washed by water. The crude product was purified by column chromatography (0-10percent MeOH in DCM) to give compound 65 as yellow solids. (51 mg, 21percent yield). 1H NMR (400 MHz, DMSO-d6) delta 11.91 (s, 1H), 9.12 (s, 1H), 8.08 (s, 1H), 7.30-7.00 (m, 5H), 6.70 (b, 1H), 5.75 (b, 1H), 5.54 (br, 1H), 4.02 (br, 1H), 3.32 (m, 1H), 3.12 (m, 1H), 2.80 (m, 1H), 2.32 (m, 1H), 2.16 (s, 3H), 1.98 (m, 1H), 1.82 (m, 1H), 0.88 (m, 2H), 0.62 (m, 2H); ESI-MS: calcd for (C21H25N7) 375, found 376 (MH+).
As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.
Reference：
Patent; NantBio, Inc.; Tao, Chunlin; Wang, Qinwei; Asad, Sharif; Weingarten, Paul; Ci, Sherry; US2018/346451; (2018); A1;,
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